Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase

Bioorg Med Chem Lett. 2002 Apr 8;12(7):1071-4. doi: 10.1016/s0960-894x(02)00080-x.

Abstract

Telomeric G-rich single-stranded DNA can adopt a G-tetraplex structure which has been shown to inhibit telomerase activity. We have examined benzoindoloquinolines derivatives for their ability to stabilize an intramolecular G-quadruplex. The increase in T(m) value of the G-quadruplex was associated with telomerase inhibition in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / chemistry*
  • DNA, Single-Stranded / chemistry*
  • G-Quadruplexes
  • Guanine / chemistry
  • Humans
  • Inhibitory Concentration 50
  • Ligands
  • Molecular Structure
  • Nucleic Acid Conformation
  • Quinolines / chemistry
  • Quinolines / metabolism*
  • Quinolines / pharmacology*
  • Taq Polymerase / antagonists & inhibitors
  • Taq Polymerase / chemistry
  • Telomerase / antagonists & inhibitors*
  • Telomerase / chemistry
  • Telomere / enzymology

Substances

  • DNA, Single-Stranded
  • Ligands
  • Quinolines
  • Guanine
  • DNA
  • Taq Polymerase
  • Telomerase